Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-07
1998-04-28
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241861, 435 691, 435 693, 4351733, 4353201, 4352523, 4352402, 4352542, 536 2372, A61K 3912, C12N 700, C12N 1537, C12N 704
Patent
active
057441421
ABSTRACT:
Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.
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Kirnbauer Reinhard
Lowy Douglas R.
Schiller John T.
Mosher Mary E.
The United States of America as represented by the Department of
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