Self-assembling polynucleotide delivery method

Details Self-assembling polynucleotide delivery method Self-assembling polynucleotide delivery method

1995-06-07

1999-11-02

Marschel, Ardin H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 253, A61K 4800

Patent

active

059770848

ABSTRACT:
This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via noncovalent interactions with the polynucleotide. The components of this system include DNA-masking components, cell recognition components, charge-neutralization and membrane-permeabilization components, and subcellular localization components. Specific compounds useful in this system are also provided.

REFERENCES:
Stull et al. Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects. Pharmaceutical Research. 12(4):465-483, 1995.
Christoffersen et al. ribozymes as human therapeutic agents. The Journal of Medicinal Chemistry. 38(12):2023-2037, 1995.
Gao et al. A Novel Cationic Liposome Reagent for Efficient Transfection of Mammalian Cells. Biochemical and Biophysical Research Communications, 179(1):280-285, 1991.

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