Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1997-11-07
1999-10-12
Saunders, David
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424 153, 424 934, 4241741, 4241811, 514 44, 5303915, 5303919, 536 231, A61K 3170, A61K 39395
Patent
active
059651334
ABSTRACT:
The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.
REFERENCES:
patent: 4478914 (1984-10-01), Glese
patent: 4676980 (1987-06-01), Segal et al.
patent: 5026785 (1991-06-01), Mage et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5177000 (1993-01-01), Bazinet et al.
patent: 5256395 (1993-10-01), Barbet et al.
patent: 5273882 (1993-12-01), Snitman et al.
patent: 5328985 (1994-07-01), Sano et al.
patent: 5338532 (1994-08-01), Tomalia et al.
patent: 5482698 (1996-01-01), Griffiths
patent: 5561043 (1996-10-01), Cantor et al.
patent: 5635602 (1997-06-01), Cantor et al.
patent: 5656739 (1997-08-01), Cubicciotti
patent: 5733523 (1998-03-01), Kuijpers et al.
Sano et al Bio/Technology, 9, 1378-1381, 1991.
"Amplifying DNA Probe Signals: A `Christmas Tree` Approach," Bio/Technology, vol. 6, pp. 1165-1168, Oct. 1998.
"Affinity Capture Electrophoresis for Sequence-Specific DNA Purification," GATA, 9(3): 96-99, 1992.
"Sequence-specific DNA purification by triplex affinity capture," Proc. Natl. Acad. Sci. USA, vol. 89, pp. 495-498, Jan. 1992.
"Immuno-PCR with a Commercially Available Avidin System," Science, vol. 260, pp. 698-699, Apr. 1993.
"Atomic force microscopy of biochemically tagged DNA," Proc. Natl. Acad. Sci. USA, pp. 3811-3814, May 1993.
"Aviden and Strept Avidin", N. M. Green, In: Wilcheck, M. & bayer, E.A. ed., Methods in Enzymology, v. 184, San Diego: Academic Press 1991, pp. 51-67.
"Biotinylated Nucleotides for Labeling and Detecting DNA", Klevan et al., In: Wilchek, M & Bayer E.A., Methods in Enzymology,v. 184, pp. 561-577, San Diego: Academic Press, 1991.
Cantor Charles R.
Hnatowich Donald J.
Niemeyer Christof M.
Rusckowski Mary
Sano Takeshi
Saunders David
Trustees of Boston University
Univ. of Mass. Medical Center
LandOfFree
Self-assembling multimeric nucleic acid constructs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Self-assembling multimeric nucleic acid constructs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Self-assembling multimeric nucleic acid constructs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-649427