Self-assembling heteropolymetallic chelates as imaging agents an

Details Self-assembling heteropolymetallic chelates as imaging agents an Self-assembling heteropolymetallic chelates as imaging agents an

1998-08-28

2000-05-02

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

534 14, 424 111, A61K 5100, A61M 3614

Patent

active

060569395

ABSTRACT:
Metal complexes of new ligands of the formula ##STR1## are useful as agents for medical imaging, particularly MRI, for in vitro or in vivo diagnostic or as radiopharmaceuticals. In these compounds, X--R.sup.1 --Y is a coordinating group able to form a highly stable complex with metal ions. Suitable units are for example derivatives of ortho-phenanthroline or of an hydroxamic acid. R.sup.2 and R.sup.3 are reactive functions such as amines or carboxylic groups. R.sup.4 and R.sup.5 are ligands, for instance diethylenetriaminepentaacetic acid 1,4,7,10-tetraacetic acid (DTPA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) or 1,4,8,11-tetraazacyclotetradecane-N, N', N", N'"-tetraacetic acid (TETA), of a different type than the X--R.sup.1 --Y units and able to strongly encapsulate metal ions with which the X--R.sup.1 --Y moieties form less stable chelates. Stable high molecular weight multimetallic entities are spontaneously formed by these ligands that spontaneously associate around metal ions through the X--R.sup.1 --Y units. Higher relaxivities thus are achieved. Mixed-complexes containing two different radionuclides are also obtained thus allowing imaging and therapy with one single chelate.

REFERENCES:
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 5250672 (1993-10-01), Sadler et al.
patent: 5284647 (1994-02-01), Niedbala et al.
patent: 5358704 (1994-10-01), Desreux et al.
Spectrochim, Acta 49A, 1315-1322, 1993 (Aime et al).
Angew. Chem. Int. Ed. Engl. 30, 1139-1141, 1991 (Blake et al).
Inorg. Chem., 31:741-746, 1992 (Benelli et al).
J. Chem. Soc., Dalton, Trans., 409-412, 1993 (Benelli et al).
J. Magn. Reson. Imaging, 7, 472-477, 1997 (Dupas et al).
J. Nucl. Med., 38, 1180-1185, 1997 (DeNardo et al).
Bioconjugate Chem., 9, 87-93, 1998 (Williams et al).
Inorg. Chem., 37, 577-589, 1998 (Martin et al).
Helv. Chim. Acta, 78, 1651-1672, 1995 (Piguet et al).
Chem. Rev., 93, 1137-1156, 1993 Jurisson et al.
Pure Appl. Chem, 65, 515-520, 1993 (Kumar et al).

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