Self-assembling amphiphiles for construction of peptide secondar

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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424417, 424450, 554 1, 560 1, 530300, C07K 700, A61K 9127, C07C 5500, C07C 6900

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06096863&

ABSTRACT:
A peptide-amphiphile complex having a lipophilic portion and a peptide portion, wherein the peptide portion has a secondary structure.

REFERENCES:
patent: 4732971 (1988-03-01), DiMarchi et al.
patent: 5117009 (1992-05-01), Barany
patent: 5196566 (1993-03-01), Barany et al.
patent: 5366958 (1994-11-01), Weiner et al.
patent: 5401511 (1995-03-01), Margalit
patent: 5498420 (1996-03-01), Edgar et al.
patent: 5576419 (1996-11-01), Fields
Hantke et al, Covalent binding of lipids to protein. Eur. J. Biochem. 34: 284-296, 1973.
McLachlan, A.D., The Double helix coiled coil structure of Murein Lippoprotein from Escherichia Coli. J. Mol. Biol. 122,: 493-506, 1978.
Shimizu T, et al, (1989) Enhanced circular dichoism of self-assembled peptidic amphiphiles. Chem.Lett. 8:1341-1344, 1989.
Yu YC, et al, (Jun. 24, 1995) Study of triple-helical structure using peptide-amphiphiles. 14th American peptide symposia 515-516, 1995.
Yu et al., "Study of triple-helical structure using peptide-amphiphiles," Chemical Abstracts, 126(1), Abstract No. 8687 (1997).
F. Albericio et al., "Preparation and Application of the 5-(4-(9-Flyorenyl methyloxycarbonyl)aminomethyl-3,5-dimethoxyphenoxy)-valeric Acid (PAL) Handle for the Solid-Phase Synthesis of C-Terminal Peptide Amides under Mild Conditions", J. Org. Chem., 55, 3730-3743 (1990).
Barany et al., "Solid-phase synthesis: a silver anniversary report", Int. J. Peptide Protein Res., 30, 705-739 (1987).
Barany et al., "Solid-Phase Peptide Synthesis", The Peptides, vol. 2, Title Page, Copyright, and Table of Contents (pp. v-viii) (1980).
P. Berndt et al., "Synthetic Lipidation of Peptides and Amino Acids: Monolayer Structure and Properties", Amer. Chem. Soc., 117, 9515-9522 (1995).
Casey, "Protein Lipidation in Cell Signaling", Science, 268, 221-225 (1995).
de Bont et al., "A convenient synthesis of a lipopeptide containing a diacylglycerol moiety: preparation of a potential inhibitor of protein kinase C", Recl. Trav. Chim. Pays-Bas, 111, 222-226 (1992).
C.G. Fields et al., "Edman Degradation Sequence Analysis of Resin-Bound Peptides Synthesized by 9-Fluorenylmethoxycarbonyl Chemistry", Peptide Research, 6, 39-47 (1993).
C.G. Fields et al., "HBTU Activation for Automated Fmoc Solid-Phase Peptide Synthesis", Peptide Research, 4, 95-101 (1991).
C.G. Fields et al., "Melanoma Cell Adhesion and Spreading Activities of a Synthetic 124-Residue Triple-helical `Mini-collagen`", J. Biol. Chem., 268, 14153-14160 (1993).
C.G. Fields et al., "Minimization of Tryptophan Alkylation Following 9-Fluorenylmethoxycarbonyl Solid-Phase Peptide Synthesis", Tetrahedron Lett., 34, 6661-6664 (1993).
C.G. Fields et al., "Purification and Analysis of Synthetic, Triple-Helical `Minicollagens` by Reversed-Phase High-Performance Liquid Chromatography", Anal. Biochem.,231, 57-64 (1995).
C.G. Fields et al., "Solid-Phase Synthesis and Stability of Triple-Helical Peptides Incorporating Native Collagen Sequences", Biopolymers, 33, 1695-1707 (1993).
C.G. Fields et al., "Solid-phase synthesis of triple-helical collagen-model peptides", Lett. Peptide Sci., 3, 3-16 (1996).
G.B. Fields, NIH #DK44494 (Abstract Only), Sep. 30, 1992.
G.B. Fields, NIH #AR01929 (Abstract Only), Mar. 1, 1994.
G.B. Fields et al., "Principles and Practice of Solid-Phase Peptide Synthesis", Synthetic Peptides: A User's Guide (G.A. Grant, Ed.), W.H. Freeman and Co., N.Y., Chapter 3, pp. 77-183 (1992).
G.B. Fields et al., "Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids", Int. J. Peptide Protein Res., 35, 161-214 (1990).
G.B. Fields, "The Collagen Triple-Helix: Correlation of Conformation With Biological Activities", Connect. Tissue Res., 31, 235-243 (1995).
Grab et al., "Promotion of Fibroblast Adhesion by Triple-helical Peptide Models of Type I Collagen-derived Sequences", J. Biol. Chem., 271, 12234-12240 (1996).
Jain et al., "Synthesis of Peptidylglycophospholipids, Novel Derivatives of Muramyl-Dipeptide", Tetrahedron Lett., 22, 2317-2320 (1981).
King et al., "A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis", Int. J. Peptide Protein Res., 36, 255-266 (1990).
Lauer et al., "Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis", Lett. Peptide Sci., 1, 197-205 (1994).
Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 85, 2149-2154 (1963).
Miles et al., "Promotion of Cell Adhesion by Single-stranded and Triple-helical Peptide Models of Basement Membrane Collagen .alpha.1(IV)531-543", J. Biol. Chem., 269, 30939-30945 (1994).
Morton et al., "Platelet Aggregation by a Collagen-Like Synthetic Peptide", Thrombosis Res., 72, 367-372 (1993).
W. Prass et al., "Lipopeptides of the N-terminus of Escherichia coli lipoprotein: synthesis, mitogenicity and properties in monolayer experiments", Biochim. et Biophys. Acta, 900, 116-128 (1987).
Rao et al., "Promotion of Human Platelet Adhesion and Aggregation by a Synthetic, Triple-helical `Mini-collagen`", J. Biol. Chem., 269, 13899-13903 (1994).
M.B. Sankaram, "Membrane Interaction of Small N-Myristoylated Peptides: Implications for Membrane Anchoring and Protein-Protein Association", J. Biophys., 67, 105-112 (1994).
T. Shimizu et al., "Self-assembling properties of synthetic peptidic lipids", Biochem. et Biophys. Acta, 1147, 50-58 (1993).
Thompson et al., "Covalent Linkage of a Synthetic Peptide to a Fluorescent Phospholipid and Its Incorporation Into Supported Phospholipid Monolayers", Biochim. Biophys. Acta., 772, 10-19 (1984).
Y. Yu et al., "Self-Assembling Amphiphiles for Construction of Protein Molecular Architecture", J. Amer. Chem. Soc., 118, 12515-12520 (1996).

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