Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-06-14
2011-06-14
Forman, Betty (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C435S287200, C536S023100, C536S024300
Reexamination Certificate
active
07960104
ABSTRACT:
The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences.
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Epicentre Biotechnologies
Callow Matthew J.
Drmanac Radoje
Hauser Brian K.
Yeung George
Callida Genomics, Inc.
Forman Betty
Morgan & Lewis & Bockius, LLP
Silva Robin M.
Talukder Gargi
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