Self assembled, defective, non-self-propagating lentivirus parti

Details Self assembled, defective, non-self-propagating lentivirus parti Self assembled, defective, non-self-propagating lentivirus parti

1993-02-16

1997-05-20

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

435 691, 435 693, 4351723, 4353201, 930221, C12N 1586, C12N 1563, A61K 3921, C07K 14155

Patent

active

056311540

ABSTRACT:
Recombinant avipox viral vectors which express heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The recombinant avipox viruses can be used to produce significant amounts of the heterologous polypeptides in avian or non-avian cells. Preferably, the recombinant avipox virus is a fowlpox virus. The viral particles can also be used as immunogens and for targeted delivery of heterologous gene products and drugs.

REFERENCES:
patent: 4603112 (1986-07-01), Paoletti et al.
M.E. Perkus et al (1985) Science 229: 981-984.
R. Mann et al (1983) Cell 33: 153-159.
A. Lever et al. (1989) J. Virol. 63: 4085-4087.
G. Franchini et al (1987) Nature 328: 539-543.
D.B.Boyle and E.H. Coupar, Virus Research 10:343-356 (1988).
J. Taylor, et al., Vaccine, 6:497-503 (1988).
J. Taylor, et al., Vaccine, 6:504-508 (1988).
D.B. Boyle and B.E.H. Coupar, J. Gen. Virol., 67:1591-1600 (1986).
D.B. Boyle, et al. Virology, 156:355-365 (1987).
F. Tomley, et al., J. Gen. Virol., 69:1025-1040 (1988).
M.M. Binns, et al., Virology, 170:288-291 (1989).
J. Taylor, et al., Technological Advances in Vaccine Development, (1988), L. Lasky (Ed.), Alan R. Liss, Inc., New York, pp. 321-334.
M.M. Binns, et al. Israeli J. Vet. Med., 42:124-127 (1986).
G. Rautmann, et al., AIDS Res. Hum. Restroviruses, 5:147-157 (1989).
C.D. Gowda, et al., J. Virol., 63:1451-1454 (Mar. 1989).
G. Mazzara, et al., Modern Approaches to Vaccines, Cold Spring Harbor Laboratory, New York, (1987).
G. Gheysen, et al., Modern Approaches to New Vaccines, Cold Spring Harbor Laboratory, New York, Sep. 14-18, Abstract No. 72 (1989).
D. Gheysen, et al. Cell, 59:103 (1989).
Smith, et al., J. Virol., 64:2743-2750 (1990).
J.W. Wills, Nature, 340:323-324 (1989).
T. Shioda and H. Shibuta, Virology, 175:139-148 (1990).
O. Haffar, et al., J. Virol., 64:2653-2659 (Jun. 1990).
V. Karacostas, et al., Proc. Natl. Acad. Sci. USA, 86:8964-8967 (Nov. 1989).
M. Delchambre, et al. The EMBO J., 8:2653-2660 (1989).
Haffar et al., J. Virol. 64(6):2653-2659 (1990).

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