Self-aligning tissue growth guide

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...

Reexamination Certificate

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C435S174000, C435S382000, C606S152000, C623S011110, C623S023760

Reexamination Certificate

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08058067

ABSTRACT:
The present invention relates to artificial tissue growth guides comprising a core and an outer sleeve, which facilitates the regeneration of damaged tissues, such as nerves. The core is fixed to the sleeve at two attachment sites so that cells seeded within the core produce mechanical tension between the attachment sites. This tension aligns the cells and the fibres of the core and provides an improved substrate for tissue regeneration. Growth guides may be surgically implanted into an individual.

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Hentz et al., “The nerve gap dilemma: A comparison of nerves repaired end to end under tension with nerve grafts in a primate model”, The Journal of Hand Surgery, May 1993, pp. 417-425, XP009033626.

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