Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1989-05-12
1992-01-21
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530402, 530403, 530404, 530405, 530406, 530820, 530825, 435 695, 435 6952, 435 713, 424 851, 424 852, 424 8591, 424 92, 935 47, 514 2, 514 8, C07K 1500, A61K 3702, A61K 39104
Patent
active
050829270
ABSTRACT:
The present invention provides a chimeric protein IL4-PE40 which selectively kills IL4 receptor bearing cells. A mutant form of the protein is also provided.
REFERENCES:
patent: 4545985 (1985-10-01), Pastan
patent: 4675382 (1987-06-01), Murphy
patent: 4894443 (1990-01-01), Greenfield et al.
Yokota et al., PNAS 83, 1986, pp. 5894-5898.
Chaudhary et al., Nature, 339, 1989, pp. 394-397.
Williams Protein Engineering 1(6) 1987, pp. 493-498.
Perentesis et al., PNAS 85, 1988, pp. 8386-8390.
Olsnes et al., Pharmac Ther, vol. 15, 1982, pp. 355-381.
Dr. William Paul, editor, "Fundamental Immunology", 2nd edition, Raven Press, 1989, pp. 634-635, Tables 1 and 2.
FitzGerald David
Ogata Masato
Pastan Ira
Draper Garnette D.
Jain Mishrilal
The United States of America as represented by the Department of
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