Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-03-15
1998-03-24
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 47, 536 276, A61K 3170
Patent
active
057312966
ABSTRACT:
This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.
REFERENCES:
patent: 4364922 (1982-12-01), Berne et al.
patent: 4673563 (1987-06-01), Berne et al.
patent: 5070877 (1991-12-01), Mohiuddin et al.
patent: 5104859 (1992-04-01), Sollevi
patent: 5231086 (1993-07-01), Sollevi
Sollevi et al., "Cardiovascular Effects of Adenosine in Man," Acta Physiologica Scandanavica, 120(2), p. 11A, Abstract C16 (Feb. 1984).
Sollevi et al., "Cardiovascular Effects of Adenosine During Controlled Hypotension in Cerebral Aneurysm Surgery," Anesthesiology(Circulation II), 59(3), p. A9 (Sep. 1983).
Sollevi et al., "Relationship between Arterial and Venous Adenosine Levels and Vasodilation During ATP-and Adenosine-Infusion in Dogs." Acta Physiol. Scand., 120, 171-176 (1984).
Olsson et al., "Coronary Vasoactivity of Adenosine in the Conscious Dog," Circulation Res., 45, 468-478 (1979).
Drury et al., "The Physiological Activity of Adenine Compounds with Especial Reference to Their Action Upon the Mammalian Heart," J. Physiol. (Cambridge), 68, 213-237 (1929).
Fukunaga et al. (I), "Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside," Anesthesia and Analgesia, 61(3), 273-278 (Mar. 1982).
Fukunaga et al. (II), "ATP-Induced HypotensiveAnestesia During Surgery," Anesthesia and Anesthesiology, 57(3), A65 (1982).
Kassell et al., "Cerebral and Systemic Circulatory Effects of Arterial Hypotension Induced by Adenosine," J. Neurosurgery, 58, 69-76 (1983).
Pantely & Bristow, "Adenosine--Renewed Interest in an Old Drug," Circulation, 82(5), 1854-1856 (1990); supplied by applicant.
Raymond H. Vaerhaeghe, "Action of Adenosine and Adenine Nucleotides on Dogs' Isolated Veins," Am. J. Physiol., 33(1), H114-H121, 1977.
J.G. De Mey and P.M. Vanhoutte, "Heterogeneous Behavior of the Canine Arterial and Venous Wall," Circulation Research, vol. 51, No. 4, Oct. 1982, pp. 439-447.
C.M. Brown and M.G. Collis, "Adenosine A.sup.1 Receptor Inhibition of Nerve Stimulation-Induced Contractions of the Rabbit Portal Vein," European Journal of Pharmacology, 93 (1983) 277-282.
Arthur C. Guyton, "Textbook of Medical Physiology," 8th Edition, Ch. 20, pp. 221-223, 1991.
Edlund et al., "Haemodynamic and Metabolic Effects of Infused Adenosine in Man," Clinical Science, 79, pp. 131-138, 1990.
Gustafsson et al. (I), "Effect of System Adenosine Infusion on Capillary Flow and Oxygen Pressure Distributions in Skeletal Muscle of the Rabbit," Int. J. Microcirc. Clin. Exp. 13: 1-12, 1993.
Sylven et al., "Flow and Pressure Responses of Coronary Arteries and Veins to Vasodilating Agents," Can. J. Physiol. Pharmacol., vol. 62, pp. 1365-1373, 1984.
Crane L. Eric
Item Development AB
Kight John
LandOfFree
Selective vasodilation by continuous adenosine infusion does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Selective vasodilation by continuous adenosine infusion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective vasodilation by continuous adenosine infusion will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2289033