Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-04-18
2006-04-18
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S195000, C435S091500, C435S023000, C435S069700, C424S094610, C424S183100, C530S350000, C530S391700, C536S023200
Reexamination Certificate
active
07029899
ABSTRACT:
This invention provides RNase A superfamily polypeptides with modified amino terminal which can be used to selectively kill target Kaposi's sarcoma cells, neoplastic endothelial cells, and non-neoplastic endothelial cells. In certain embodiments of the invention, the amino terminal modification consists of an addition of 4 amino acid sequence consisting of the SLHV sequence at position −4 to −1 to the eosinophil derived neurotoxin protein. The amino terminal addition is capable of directing the claimed RNase A superfamily polypeptides to proliferating endothelial cells, such as Kaposi's sarcoma cells, and selectively killing these cells.
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Newton Dianne L.
Rybak Susanna M.
Gebreyesus Kagnew
Prouty Rebecca E.
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
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