Selective synthesis of CF3-substituted pyrimidines

Details Selective synthesis of CF3-substituted pyrimidines Selective synthesis of CF3-substituted pyrimidines

2006-10-17

2006-10-17

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S331000, C544S324000, C514S275000

Reexamination Certificate

active

07122670

ABSTRACT:
The present invention relates to a method of making a compound of the formulawherein X1, X2and R3—R4are as defined herein. The method includes reacting a compound of the formulawith an amine of formula 3 (HNR3R4) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.

REFERENCES:
patent: 03030909 (2003-04-01), None
Diringer et al., Journal of Medicinal Chemistry, vol. 13, No. 1, pp. 151-152 (1970).

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