Selective stabilization of protein during viral inactivation

Details Selective stabilization of protein during viral inactivation Selective stabilization of protein during viral inactivation

1996-06-28

1998-07-28

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530413, 530380, 530381, 530329, 210656, C07K 300

Patent

active

057864586

ABSTRACT:
A process for viral inactivation of a solution containing a biologically active protein, wherein the process comprises the steps of 1) contacting the solution with an immobilized ligand under conditions which allow protein to bind to the ligand, 2) subjecting the bound protein to a viral inactivation method under conditions which would result in substantial denaturation of the protein if it were not bound to the ligand, and 3) recovering the protein by washing the immobilized protein under conditions which favor the release of the protein into the solution under conditions in which the recovered protein retains its biological activity.

REFERENCES:
patent: 4673733 (1987-06-01), Chandra et al.
patent: 4831012 (1989-05-01), Estep

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