Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-02-05
1995-05-16
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
210644, 210645, 210649, 210650, 210651, 210660, 210661, 536 187, 536124, 527300, 527312, 604 4, 604 5, 604 6, B01D 6100, B01D 6302, B01D 1508, C07H 100
Patent
active
054161983
ABSTRACT:
A polycationic system for the removal of polyanions from a fluid medium is formed by, first, activating a biocompatible hydroxylated support with an organic sulfonyl chloride, such as p-toluene-sulfonyl chloride, in the presence of a dialkylamino pyridine activation catalyst, such as 4-dimethylamino-pyridine (DMAP). The activated support is then reacted with a polymer having a polyamide backbone with pendent alkyl amine groups, such as poly-L-lysine (PLL), to form C--N bonds between an activated carbon from the hydroxylated polymer and an amine group from the polymeric polyamide. Finally, any unreacted activated sites on the hydroxylated polymer are capped or removed with an effective amount of capping agent such as a mercapto (--SH), hydroxy (--OH) or amino (--NH.sub.2) containing compound which reacts with the unreacted activated sites. The pendent alkyl amines on the polyamide backbone exist, at the appropriate pH, as polycations. The polyanion, such as heparin, is removed from fluids, such as blood plasma and whole blood, by bringing these fluids in contact with the polycationic system. The polyanion is bound to the polycation system by ionic attraction. The polyanion can then be released from the polycation system by treatment with a basic solution, thereby allowing the system to be reused.
REFERENCES:
patent: 4062882 (1977-12-01), Sen Gupta
patent: 4883598 (1989-11-01), Riethorst et al.
patent: 4923439 (1990-05-01), Seidel et al.
patent: 4968432 (1990-11-01), Antwiler
patent: 5084398 (1992-01-01), Huston et al.
patent: 5151192 (1992-09-01), Matkovich et al.
patent: 5173470 (1992-12-01), Bruening et al.
patent: 5183872 (1993-02-01), Heidel et al.
patent: 5211850 (1993-05-01), Shettigar et al.
Anderson Christopher G.
McRea James C.
Griffin Ronald W.
Research Medical Inc.
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