Selective removal of albumin from blood fluids and compositions

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260 8, 260121, A23J 100, C07G 700

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active

040936120

ABSTRACT:
Certain compositions have been prepared by the reaction of certain dyes of the class generally known as Color Index reactive dyes with certain support phases. The dyes utilized for said compositions all possess the general sulfanilido-triazidinyl-sulfoaryl group wherein the aryl groups may be phenyl or naphthyl and said general group is further bonded to aryl groups via an amino or azo linkage. It has been found that when aqueous fluids containing albumin, such as, for example, plasma or serum are passed over compositions within the scope of the present invention albumin is selectively adsorbed on said compositions without removal of other proteins present in the fluid. It has further been found that the albumin may be readily removed from the thus formed adsorbate without denaturing the albumin and leaving the solid phase dye composition in a suitable state for re-use without loss of activity.

REFERENCES:
patent: 4016149 (1977-04-01), Travis et al.
Behring Inst. Mitt. 54, 30-32 (1974), Travis et al.
Clin. Chim. Acta, 49, pp. 49-52, 1973, Travis et al.
Chem. Abst., vol. 83, 1975, 24718e, Travis et al.
Chem. Abst., vol. 81, 1974, 165663d, Travis et al.

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