Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-04-07
1996-02-27
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514177, 514182, 514841, 514843, 530399, 530850, 530851, 530852, 530853, 530854, C07K 14575, C07K 1459, A61K 3156, A61K 3824
Patent
active
054948991
ABSTRACT:
It has been determined that estrogen and other hormones elevated in pregnancy induce a specific modulation of lymphocyte precursor cell production. The immune system of an animal or bone marrow cells in culture can therefore be modulated in a specific manner by administration of hormones elevated during pregnancy, such as estrogen and estrogen-like compounds or compounds that interfere with the synthesis or activity of these hormones, to increase or decrease production of B lymphocyte precursor cells.
REFERENCES:
patent: 4383993 (1983-05-01), Hussain et al.
patent: 4885290 (1989-12-01), Asano et al.
patent: 4894373 (1990-01-01), Young
patent: 4900734 (1990-02-01), Maxson et al.
Kotani, et al. "Effects of Estrogen on the Lymphac Regeneration & Immune Response In Irradiated & Marrow Reconstituted Mice" Acta Anat. 105 298-308 1979.
Nikolaevich, et al. "Major Reproduction Hormones as Regulators of Cell to Cell Interactions In Humoral Immune Responses" Brain, Behav., Immun. 5 149-161 1991.
Chakraborty et al. "Effects of Long-Term Treatment w/Estradiol or Clomiphene Citate On Bone Maintenance and Pituitery & uterine weights In Ovariectomyed Rats" J Steroid Biochem Molec. Biol. 40(4-6) 725-729 1991.
Gray et al. "Hormones In Blood" pp. 148-149 1983.
VanVoorhis et al. "The Effects of RU 486 on Immune Function & Steroid-Induced Immunosuppression In Vitro" J. Clin. Endonin Metab. 69(6) 1195-1191 1989.
Greenstein et al. "Aromatase Inhibitors Regenerate The Thymus In Aging Male Rats" Int J Immunopharmacol. 14 (4) 541-553 1992.
Beamer, W. G., et al., "Granulosa Cell Tumorigenesis in Genetically Hypogonadal-immunodeficient Mice Grafted with Ovaries from Tumor-susceptible Donors," Cancer Res. 53:3741-3746 (Aug. 15, 1933).
Engelhard, D., et al., "Cycling of Peripheral Blood and Marrow Lymphocytes in Cyclic Neutropenia," Proc. Natl. Acad. Sci. 80:5734-5738 (Sep. 1983).
Kincade Paul W.
Medina Kay
Degen Nancy J.
Oklahoma Medical Research Foundation
Wityshyn Michael G.
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