Selective protein tyrosine phosphatatase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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C560S009000, C560S024000, C560S026000, C560S027000, C560S030000, C560S033000, C560S075000, C560S102000, C560S109000, C560S111000, C560S112000, C560S153000

Reexamination Certificate

active

06972340

ABSTRACT:
Compounds of formula (I)or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.

REFERENCES:
patent: 3987192 (1976-10-01), Wright
patent: 4091011 (1978-05-01), Wright
patent: 4230484 (1980-10-01), Batch et al.
patent: 2002/0035137 (2002-03-01), Liu et al.
patent: 2002/0169157 (2002-11-01), Liu et al.
patent: 1517896 (1968-03-01), None
patent: 99/46236 (1999-09-01), None
patent: 9946237 (1999-09-01), None
patent: 01/17516 (2001-03-01), None
patent: 01/19830 (2001-03-01), None
patent: 01/19831 (2001-03-01), None
patent: 0218323 (2002-03-01), None
Iversen, L.R., et al., “Structure-based Design of a Low Molecular Weight, Nonphosphorus, Nonpeptide, and Highly Selective Inhibitor of Protein-tyrosine Phosphatase 1B”,Journ. Of Biol. Chem., 275(14):10300-10307 (2000).
Peters, G. H., et al., “Residue 259 Is a Key Determinant of Substrate Specificity of Protein-tyrosine Phosphatases 1B and α*”,Journ. Of Biol. Chem., 275(24):18201-18209 (2000).
Tony Hunter, “The Phosphorylation of proteins on tyrosine: its role in cell growth and disease”, Phil. Trans. R. Soc. Lond. B (1998) 353: 583-605.
Chan et al, “The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction”, Annu. Rev. Immunol. (1994) 12: 555-592.
Zhong-Yin Zhang, “Structure, Mechanism, and Specificity of Protein-Tyrosine Phosphatases”, Current Topics In Cellular Regulation (1997) 35:21-68.
Matozaki et al, “Roles of Protein-Tyrosine Phosphatases in Growth Factor Signalling”, Cell. Signal (1996) vol. 8, No. 1: 113-119.
Barry J. Goldstein, “Regulation of Insulin Receptor Signaling by Protein-Tyrosine Dephosphorylation”, Receptor (1993) 3:1-15.
Faure et al, “The Dephosphorylation of Insulin and Epidermal Growth Factor Receptors”, Journal of Biol. Chemistry (1992) 267:11215-11221.
Seely et al., “Protein Tyrosine Phosphatase 1B Interacts with the Activated Insulin Receptor”, Diabetes (1996) 45: 1379-1385.
Ahmad et al, “Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-Tyrosine Phosphatase 1 B in Negative Regulation of the Insulin Action Pathway”, J. Biol. Chem. (1995)270:20503-20508.
Elchebly et al, “Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene”, Science (1999) 283: 1544-1548.
Klaman et al, “Increased Energy Expenditure, Decreased Adiposity and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphastase 1B-Deficient Mice”, Molecular and Cellular Biology (2000) 20: 5479-5489.
Hunter et al, “Protein-Tyrosine Kinases”, Ann. Rev. Biochem (1985) 54:897-930.
Wiener et al, “Overexpression of the Protein Tyrosine Phosphatase PTPIB in Human Breast Cancer: Association with p185c-erB-2 Protein Expression”, J. Natl. Cancer Inst. (1994) 86: 372-378.
Noguchi et al, Role of SH-PTP2, a Protein-Tyrosine Phosphatase with Src Homology 2 Domains, in Insulin-Stimulated Ras Activation:, Molecular Cellular Biology (1994) 14:6674-6682.
Flint et al, “Multi-site phosphorylation of the protein tyrosine phosphatase, PTPIB: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation”, The EMBO Journal (1993) 12: 1937-1946.
Mauto et al, “Identification of a Hormonally Regulated Protein Tyrosine Phosphatase Associated with Bone and Testicular Differentiation”, Journal of Biological Chemistry (1994) 269: 30659-30667.
Wang et al, “Mechanism of Inhibition of Protein-Tyrosine Phosphatases by Disodium Aurothiomalate”, Biochemical Pharmacology (1997) 54:703-711.
Mauro et al, “Zip Codes′ direct intracellular protein tyrosine phosphatases to the correct cellular ‘address’”, TIBS (1994) 19: 151-155.
Tonks et al, “Purification of the Major Protein-tyrosine-phosphatases of Human Placenta”, J. Biol. Chem. (1998) 263: 6722-6730.
Cool et al, “cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family”, Proc. Natl. Acad. Sci. USA (1989) 86: 5257-5261.
Lombroso et al, “Molecular characterization of a protein-tyrosine-phosphatase enriched striatum”, Proc. Natl. Acad. Sci. USA (1991) 88: 7242-7246.
Plutzky et al, “ Isolation of a src homology 2-containing tyrosine phosphatase”, Proc. Natl. Acad. Sci USA (1992) 89: 1123-1127.
Vogel et al, “Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation”, Science (1993) 259: 1611-1614.
Feng et al, “SH2-Containing Phosphotyrosine Phosphatases as a target of Protein-Tyrosine Kinases”, Science (1993) 259: 1607-1611.
Ralph et al, “Structural Variants of Human T200 glycoproetin (leukocyte-common antigen)” The EMBO Journal (1987) 6: 1251-1257.
Streuli et al, “A New Member of the Immunoglobulin Super Family that has a Cytoplamic Region Homologous to the Leukocyte Common Antigen”, J. Exp. Med. (1988) 168(5): 1523-1530.
Krueger et al, “Structural Diversity and Evolution of Human Receptor-Like Protein Tyrosine Phosphatases”, The EMBO Journal (1990) 9: 3241-3252.
Beaulieu et al, “Ligands for the tyrosine kinase p561ck SH2 domain: Discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements” J. Med. Chem. (1999) 42: 1757-1766.
Andersen et al, “2-(Oxalylamino)-benzoic acid Is a general, competitive inhibitor of protein-tyrosine phosphatases” J. Biol. Chem. (2000) 275: 7101-7108.
Iversen et al, “Structure-based design of a low molecular weight nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B”, J. Biol. Chem. (2000) 275: 10300-10307.
Abstract XP002195161. Podesva, C et al: Canadian Journal of Chemistry (1968) 46: 435-439.
Abstract XP002195162. Peet, Norton P. et al: Journal of Heterocyclic Chemistry (1980) 17: 1513-1518.
Abstract XP002195163. Lee, Sang-Gi et al: Synthetic Communications (1996) 26: 4623-4632.
Abstract XP002195164. Ye, Jia-Hai et al: Tetrahedron Letters (1999) 40: 1365-1368.
Abstract XP002195166. Cannizzo, Sergio et al: Journal of Heterocyclic Chemistry (1990) 27:2175-2179.

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