Selective process for the deacylation and deacetylation of taxol

Details Selective process for the deacylation and deacetylation of taxol Selective process for the deacylation and deacetylation of taxol

1994-07-18

1997-05-13

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30514

Patent

active

056294336

ABSTRACT:
The present invention relates to a highly selective method for the deacetylation and deacylation of taxol and taxanes compounds. Specifically, the present invention relates to a one step process wherein acyl groups located at the carbon 2', 10, and 7 positions of taxol and other taxane compounds may be selectively removed.

REFERENCES:
patent: 4857653 (1989-08-01), Colin et al.
patent: 5200534 (1993-04-01), Rao
patent: 5256801 (1993-10-01), Carver et al.
patent: 5274137 (1993-12-01), Nicolaou et al.
"Promotion of Microtubule Assembly in vitro by Taxol", Nature vol. 277:665-667 (1979) by S. Horwitz et al.
"Modified Taxols. 5. Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity", J. Org. Chem 56:5114-5119 (1991) by Kingston et al.
"The Chemistry of Taxanes: Reaction of Taxol and Baccatin Derivatives with Lewis Acids in Aprotic and Protic Media" Tetrahedron vol. 49, No. 14, pp. 2805-2828 (1993) by Chen et al.

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