Selective preventives/remedies for progressive lesions after...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S175000, C514S470000

Reexamination Certificate

active

06878745

ABSTRACT:
Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the induction of cytotoxic effecter macrophages which are induced into damaged organ tissues in response to chemokines or cytokines expressed depending on the type of the damaged organ tissues.

REFERENCES:
patent: 45-20956 (1970-07-01), None
patent: 04-338331 (1992-11-01), None
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M. Ishibashi et al., Attenuation of Glomerular Epithelial Cell Innury and Diminution of Tubulointerstitial Lesions by a Macrophage Inhibitor in Chronic Puromycin-nephrosis model. Nephrology, 1997; 3 (Suppl. 1): S44.
M. Ishibashi et al., Combined use of Selective Inhibitor of Macrophage-effector Generation for Treatment of Differential Glomerular and Tubulointerstitial Lesion of Progressive Renal Diseases. Abstract submitted to the 35th Amer. Soc. of Nephrology, Pennsylvania, Oct. 30-Nov. 4, 2002.

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