Selective preamplifier of cell potentials

Details Selective preamplifier of cell potentials Selective preamplifier of cell potentials

1978-05-10

1980-12-23

Cohen, Lee S.

Surgery

Truss

Pad

128902, A61B 504

Patent

active

042404436

ABSTRACT:
There is disclosed an apparatus for the selective detection and controlled gain of intranuclear and intracellular potentials. Such apparatus contains an amplifier with a gain control, such amplifier having an input terminal and an output terminal and several stages each containing an integrated active electronic device. The input terminal is the input terminal of the integrated active device of the first stage, such input terminal being directly coupled by a double screened lead with a metallic microelectrode for collecting intracell and intranuclear biopotentials. The apparatus further includes a circuit for isolating the reference point of the first said stage, as compared to the null point of the power supply of the said apparatus, so that the reference point of the first stage floats according to the bioelectric signal applied at the input of the first stage, and a circuit for neutralizing the offset voltages in the stages of said amplifier, thus obtaining a good equality between the floating potential of the reference point of the first stage and the potential applied at the input terminal of the same stage. In a preferred embodiment the amplifier is directly coupled with the input terminal of a variable time constant integrator, and the stages of the amplifier are directly coupled without the use of any capacitors, thereby obtaining an improved signal to noise ratio.

REFERENCES:
patent: 3498288 (1970-03-01), Max et al.
patent: 3580243 (1971-05-01), Johnson
Allen et al., "An Automatic DC Level Comp. Circ. . . .", IEEE Trans. Bio. Med. Eng., vol. 20, Jan. 1973, pp. 58-60.
Belgum, "Automatic Offset of DC Membrane Potentials", Electroencephalography and Clin. Neur., vol. 42, No. 2, pp. 275-276, Feb. 1977.
Thompson et al., "An Improved Method for Extracellular Recording . . .", MBE, v. 13, #1, Jan. 1975, pp. 104-106.

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