Selective nuclear receptor-targeted systems for delivery of...

Details Selective nuclear receptor-targeted systems for delivery of... Selective nuclear receptor-targeted systems for delivery of...

2006-05-02

2006-05-02

Qazi, Sabiha (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C552S502000, C514S185000, C514S169000, C514S170000, C514S171000, C514S182000, C514S179000, C534S015000, C435S002000

Reexamination Certificate

active

07038041

ABSTRACT:
An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The method of invention exploits an active process that involves strong and specific interactions between nuclear receptor and its cognate ligand.

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Shanmugathasan et al., Regioselective halogenation and palladium-catalysed couplings on 5,15-diphenylporphyrin, Journ of Porphyrins and Phthalocyanines (2000), 4(3), 228-232, AN 2000:251139 HCAPLUS, DN 132:347438.
Chen et al., “Chemical Studies of Estrogenic Steriod-Porphyrins, Part III, Synthesis of Estrogenic Steroid-Porphyrins and Their Metal Complexes”, Youji Huaxue, May 1992, vol. 12, No. 1, pp 102-106.
Chen et al., Chemistry of Steroid-Porphyrins. I Synthesis of Steroid-Porphyrins Compounds, Youji Huaxue, Oct. 12, 1998, vol. 8, No. 1, pp 34-36.
Boyle et al., Iodination and Heck Alkylation of 5,15-diphenylporphyrin. A Convenient Entry to Asymmetrically Meso-substituted Porphyrins, J. Chem Soc. Commun, 1995, vol. 5, pp 527-528.

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