Selective non-steroidal glucocorticoid receptor modulators

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S406000

Reexamination Certificate

active

07411073

ABSTRACT:
The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as novel non-steroidal selective glucocorticoid receptor modulators for treating a variety of autoimmune and inflammatory diseases or conditions, and possess advantages over steroidal glucocorticoid ligands with respect to undesireable side-effects, efficacy, toxicity and/or metabolism. Pharmaceutical compositions and methods of use are also included.

REFERENCES:
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patent: 4349558 (1982-09-01), Bell
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patent: 0058841 (1984-12-01), None
patent: WO 03/086294 (2003-10-01), None
patent: WO 2004/026248 (2004-04-01), None
Kirkemo et al, “Synthesis of Methyl 3,5,9,11,13-Pentaoxotetradecanoate,a “Skipped” Heptaketide, via Ozonolysis of a Hydroaromatic System” J. Org. Chem. 1985, 50, 1316-1319.
Medline Encyclopedia for “polyarteritis nodosa” entry updated Aug. 22, 2006 at http://www.nlm.nih.gov/medlineplus/ency/article/001438.htm.

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