Selective monoacylation of substituted hydrazines

Details Selective monoacylation of substituted hydrazines Selective monoacylation of substituted hydrazines

1990-05-24

1992-11-24

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

544 8, 544 10, 564148, 564149, 564150, 564151, C07C24328, C07C24338, C07C31732

Patent

active

051663783

ABSTRACT:
Mono-acylated hydrazines are prepared in high yield by reaction of a hydrazine salt with an azole derivative of acyl halide in the presence of a strong base. Useful hydrazine salts include those of the formula RNHNH.sub.2 .multidot.HX, where R is alkyl, aryl, aralkyl, acyl, aroyl, heterocyclic or heteroaryl, and HX is a mineral or organic acid. Useful azole derivatives include those of the formula R'CO--A, where R' is alkyl, aryl, aralkyl, heterocyclic or heteroaryl and A is an azole radical such as pyrrole, imidazole, pyrazole, triazole, tetrazole, indole or benzimidazole.

REFERENCES:
patent: 4803277 (1989-02-01), Shiokawa et al.
Synthesis, Nov. 1990, R. S. Hosmane et al, "Synthesis of a Novel Ring-Expanded Xanthine Analogue and Several Methyl or Benzyl Derivatives Containing the 5:7-Fused Imidazo [4,5-e][1,2,4] Triazepine Ring System" pp. 1095-1100.

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