Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-06-05
2000-02-08
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514763, 514768, A61K 3119, A61K 31015, A61K 3101
Patent
active
060228970
ABSTRACT:
In accordance with the present invention, there are provided a class of compounds which are capable of selectively modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-.gamma.). The identification of such compounds makes possible the selective intervention in PPAR-.gamma. mediated pathways, without exerting inadvertent effects on pathways mediated by other PPAR isoforms.
REFERENCES:
patent: 4016184 (1977-04-01), Morton, Jr.
patent: 4049678 (1977-09-01), Peterson
Bardot et al., "PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene" Biochem. Biophys. Res. Comm. 192(1):37-45 (1993).
Berger et al., "Interaction of Glucocorticoid Analogues with the Human Glucocorticoid receptor" J. Steroid Biochem. Molec. Biol. 41(3-8):733-738 (1992).
Gearing et al., "Interaction of the Peroxisome-Prolifertor-Activated Receptor and Retinoid X Receptor" Proc. Natl. Acad. Sci. USA 90:1440-1444 (1993).
Giguere et al., "Identification of a Receptor for the Morphogen Retinoic Acid" Nature 330:624-629 (1987).
Gottlicher et al., "Fatty Acids Activate a Chimera of the Clofibric Acid-Activated Receptor and the Glucocorticoid Receptor" Proc. Natl. Acad. Sci. USA 89:4653-4657 (1992).
Hall et al., "Expression and Regulation of Escherichia coli lacZ Gene Fusions in Mammalian Cells" J. Mol. Appl. Genet 2(1):101-109 (1983).
Heyman et al., "9-Cis Retinoic Acid is a High Affinity Ligand for the Retinoid X Receptor" Cell 68:397-406 (1992).
Hollenberg and Evans, "Multiple and Cooperative Trans-Activation Domains of the Human Glucocorticoid Receptor" Cell 55:899-906 (1988).
Issemann and Green, "Activation of a Member of the Steroid Hormone Receptor Superfamily by Peroxisome Prolifertors" Nature 347:645-650 (1990).
Keegan et al., "Separation of DNA Binding from the Transcription-Activating Function of a Eukaryotic Regulatory Protein" Science 231:699-704 (1986).
Keller et al., "Fatty Acids and Retinoids Control Lipid Metabolism Through Activation of Peroxisome Proliferator-Activated Receptor-Retinoid X Receptor Heterodimers" Proc. Natl. Acad. Sci. USA 90:2160-2164 (1993).
Kliewer et al., "Convergence of 9-cis Retinoic Acid and Peroxisosme Proliferator Signalling Pathways Through Heterodimer Formation of Their Receptors" Nature 358:771-774 (1992).
Lazarow and Fujiki, "Biogenesis of Peroxisomes" Ann. Rev. Cell Biol. 1:489-530 (1985).
Levin et al., "9-Cis Retinoic Acid Stereoisomer Binds and Activates the Nuclear Receptor RXR.alpha." Nature 355:359-361 (1992).
Luckow and Schutz, "CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements" Nucleic Acid Research 15(13):5490 (1987).
Mangelsdorf et al., "Nuclear receptor that identifies a novel retinoic acid response pathway" Nature 345:224-229 (1990).
Marcus et al., "Diverse Peroxisome Proliferator-Activated Receptors Bind to the Peroxisome Proliferator-Response Elements of the Rat Hydratase/Dehydrogenase and Fatty Acyl-CoA Oxidase Genes but Differentially Induce Expression" Proc. Natl. Acad. Sci. USA 90:5723-5727 (1993).
Muerhoff et al., "The Peroxisome Proliferator-Activated Receptor mediates the Induction of CYP4A6, a Cytochrome P450 Fatty Acid .omega.-Hydroxylase, by Clofibric Acid" J. Biol. Chem. 267(27):19051-19053 (1992).
Nemali et al., "Comparison of Constitutive and Inducible Levels of Expression of Peroxisomal .beta.-Oxidation and Catalase Genes in Liver and Extrahepatic Tissues of Rat" Cancer Res. 48:5316-5324 (1988).
Reddy and Lalwani, "Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans" Crit. Rev. Toxicol. 12(1):1-58 (1983).
Sadowski and Ptashne, "A vector for expressing GAL4 (1-147) fusions in mammalian cells" Nucleic Acids Research 17(18):7539 (1989).
Tugwood et al., "The Mouse Peroxisome Proliferator Activated Receptor Recognizes a Response Element in the 5' Flanking Sequence of the Rat Acyl CoA Oxidase Gene" EMBO J. 11(2):433-439 (1992).
Umesono et al., "Direct Repeats as Selective Response Elements for the Thyroid Hormone, Retinoic Acid, and Vitamin D.sub.3 Receptors" Cell 65:1255-1266 (1991).
Vamecq and Draye, "Pathophysiology of Peroxisomal .beta.-Oxidation" Essays Biochem. 24:115-225 (1989).
Webster et al., "The Hormone-Binding Domains of the Estrogen and Glucocorticoid Receptors Contain an Inducible Transcription Activation Function" Cell 54:199-207 (1988).
Forman et al., "15-Deoxy-Delta.sup.12, 14 -Prostaglandin J.sub.2 Is a Ligand for the Adipocyte Determination Factor PPAR Gamma" Cell 83:803-812 (1995).
Greene et al., "Isolation of the Human Peroxisome Proliferator Activated Receptor Gamma cDNA: Expression in Hematopoietic Cells and chromosomal Mapping" Gene Expression 4:281-299 (1995).
Kliewer et al., "Differential expression and activation of a family of murine peroxisome proliferator-activated receptors" Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
Kliewer et al., "A Prostaglandin J.sub.2 Metabolite Binds Peroxisome Proliferator-Activated Receptor Gamma and Promotes Adipocyte Differentiation" Cell 83:813-819 (1995).
Lehmann et al., An antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor Gamma(PPAR-Gamma) 270(22):12953-12956 (1995).
Yu et al., "Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids" J. Biol. Chem. 270(41):23975-23983 (1995).
Evans Ronald M.
Forman Barry M.
Criares Theodore J.
Kleinsmith David F.
Reiter Stephen E.
The Salk Institute for Biological Studies
LandOfFree
Selective modulators of peroxisome proliferator activated recept does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Selective modulators of peroxisome proliferator activated recept, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective modulators of peroxisome proliferator activated recept will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1681766