Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-02-27
2009-02-03
Bunner, Bridget E (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S252300, C435S471000, C435S069100, C530S350000, C536S023500
Reexamination Certificate
active
07485432
ABSTRACT:
Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the compound modulates one TLR-mediated cellular activity to a different extent than it modulates a second TLR-mediated cellular activity. Compounds so identified and pharmaceutical compositions including such compounds are also disclosed. Methods of selectively modulating immune cells and methods of treating certain conditions are also provided. Such methods include administering to cells or a subject a compound that selectively modulates a TLR-mediated cellular activity.
REFERENCES:
patent: 4689338 (1987-08-01), Gerster
patent: 4698348 (1987-10-01), Gerster
patent: 4929624 (1990-05-01), Gerster et al.
patent: 4988815 (1991-01-01), Andre et al.
patent: 5037986 (1991-08-01), Gerster
patent: 5175296 (1992-12-01), Gerster
patent: 5238944 (1993-08-01), Wick et al.
patent: 5266575 (1993-11-01), Gerster et al.
patent: 5268376 (1993-12-01), Gerster
patent: 5346905 (1994-09-01), Gerster
patent: 5352784 (1994-10-01), Nikolaides et al.
patent: 5367076 (1994-11-01), Gerster
patent: 5376501 (1994-12-01), Mariën et al.
patent: 5389640 (1995-02-01), Gerster et al.
patent: 5395937 (1995-03-01), Nikolaides et al.
patent: 5446153 (1995-08-01), Lindstrom et al.
patent: 5482936 (1996-01-01), Lindstrom
patent: 5494916 (1996-02-01), Lindstrom et al.
patent: 5525612 (1996-06-01), Gerster
patent: 5605899 (1997-02-01), Gerster et al.
patent: 5693811 (1997-12-01), Lindstrom
patent: 5741908 (1998-04-01), Gerster et al.
patent: 5756747 (1998-05-01), Gerster
patent: 5939090 (1999-08-01), Beaurline et al.
patent: 6028076 (2000-02-01), Hirota et al.
patent: 6039969 (2000-03-01), Tomai et al.
patent: 6069149 (2000-05-01), Nanba et al.
patent: 6083505 (2000-07-01), Miller et al.
patent: 6110929 (2000-08-01), Gerster et al.
patent: 6113918 (2000-09-01), Johnson et al.
patent: 6194388 (2001-02-01), Krieg et al.
patent: 6194425 (2001-02-01), Gerster et al.
patent: 6200592 (2001-03-01), Tomai et al.
patent: 6207646 (2001-03-01), Krieg et al.
patent: 6239116 (2001-05-01), Krieg et al.
patent: 6245776 (2001-06-01), Skwierczynski et al.
patent: 6303347 (2001-10-01), Johnson et al.
patent: 6323200 (2001-11-01), Gerster et al.
patent: 6329381 (2001-12-01), Kurimoto et al.
patent: 6331539 (2001-12-01), Crooks et al.
patent: 6339068 (2002-01-01), Krieg et al.
patent: 6376501 (2002-04-01), Isobe et al.
patent: 6376669 (2002-04-01), Rice et al.
patent: 6387938 (2002-05-01), Mizuguchi et al.
patent: 6406705 (2002-06-01), Davis et al.
patent: 6426334 (2002-07-01), Agrawal et al.
patent: 6440992 (2002-08-01), Gerster et al.
patent: 6451810 (2002-09-01), Coleman et al.
patent: 6476000 (2002-11-01), Agrawal
patent: 6514985 (2003-02-01), Gerster et al.
patent: 6518265 (2003-02-01), Kato et al.
patent: 6518280 (2003-02-01), Gerster et al.
patent: 6525028 (2003-02-01), Johnson et al.
patent: 6525064 (2003-02-01), Dellaria et al.
patent: 6541485 (2003-04-01), Crooks et al.
patent: 6545016 (2003-04-01), Dellaria et al.
patent: 6545017 (2003-04-01), Dellaria et al.
patent: 6558951 (2003-05-01), Tomai et al.
patent: 6573273 (2003-06-01), Crooks et al.
patent: 6649172 (2003-11-01), Johnson
patent: 6656938 (2003-12-01), Crooks et al.
patent: 6660735 (2003-12-01), Crooks et al.
patent: 6660747 (2003-12-01), Crooks et al.
patent: 6664260 (2003-12-01), Charles et al.
patent: 6664264 (2003-12-01), Dellaria et al.
patent: 6664265 (2003-12-01), Crooks et al.
patent: 6667312 (2003-12-01), Bonk et al.
patent: 6670372 (2003-12-01), Charles et al.
patent: 6677347 (2004-01-01), Crooks et al.
patent: 6677348 (2004-01-01), Heppner et al.
patent: 6677349 (2004-01-01), Griesgraber
patent: 6683088 (2004-01-01), Crooks et al.
patent: 2002/0016332 (2002-02-01), Slade
patent: 2002/0055517 (2002-05-01), Smith
patent: 2002/0058674 (2002-05-01), Hedenstrom et al.
patent: 2002/0110840 (2002-08-01), Tomai et al.
patent: 2003/0022302 (2003-01-01), Lewis et al.
patent: 2003/0104523 (2003-06-01), Bauer et al.
patent: 2003/0133913 (2003-07-01), Tomai et al.
patent: 2003/0139364 (2003-07-01), Krieg et al.
patent: 2003/0144283 (2003-07-01), Coleman et al.
patent: 2003/0199461 (2003-10-01), Averett et al.
patent: 2004/0010007 (2004-01-01), Dellaria et al.
patent: 2004/0014779 (2004-01-01), Gorden et al.
patent: 2004/0023870 (2004-02-01), Dedera et al.
patent: 0 394 026 (1990-10-01), None
patent: 1 104 764 (2001-06-01), None
patent: 9-208584 (1997-08-01), None
patent: 11-80156 (1999-03-01), None
patent: 11-222432 (1999-08-01), None
patent: 2000-247884 (2000-09-01), None
patent: WO 00/47719 (2000-08-01), None
patent: WO 00/75304 (2000-12-01), None
patent: WO 00/76505 (2000-12-01), None
patent: WO 00/76518 (2000-12-01), None
patent: WO 01/74343 (2001-10-01), None
patent: WO 02/36592 (2002-05-01), None
patent: WO 02/46188 (2002-06-01), None
patent: WO 02/46189 (2002-06-01), None
patent: WO 02/46190 (2002-06-01), None
patent: WO 02/46191 (2002-06-01), None
patent: WO 02/46192 (2002-06-01), None
patent: WO 02/46193 (2002-06-01), None
patent: WO 02/46194 (2002-06-01), None
patent: WO 02/46749 (2002-06-01), None
patent: WO 02/085905 (2002-10-01), None
patent: WO 02/102377 (2002-12-01), None
patent: WO 03/020889 (2003-03-01), None
patent: WO 03/043572 (2003-05-01), None
patent: WO 03/045391 (2003-06-01), None
patent: WO 03/089602 (2003-10-01), None
patent: WO 03/103584 (2003-12-01), None
Gibson et al, cellular Immunology, Aug. 2002, vol. 218, pp. 74-86.
Testerman, et al., “Cytokine Induction by the Immunomodulators Imiquimod and S-27609”,Journal of Leukocyte Biology, vol. 58, pp. 365-372, Sep. 1995.
Chollet, et al, “Development of a Topically Active Imiquimod Formulation”,Pharmaceutical Development and Technology, 4(1), pp. 35-43 (1999).
Brassard et al.; “Interferon-α as an immunotherapeutic protein”; Journal of Leukocyte Biology; vol. 71; Apr. 2002; pp. 565-581.
Izumi et al.; “1H-imidazo[4,5-c]quinoline Derivatives as Novel Potent TNF-α Suppressors: Synthesis and Structure-Activity Relationship of 1-, 2-and 4-Substituted 1H-imidazo[4,5-c]quinolines or 1H-imidazo[4,5-c]pyridines”;Bioorganic and Medicinal Chemistry, vol. 11, pp. 2541-2550 (2003).
Hornung et al., “Quantitative Expression of Toll-Like Receptor 1-10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1”,The Journal of Immunology, 2002, 168; pp. 4531-4537.
Hemmi et al., “Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent Signaling pathway”,Nature Immunology, vol. 3, No. 2; Feb. 2002; pp. 196-200.
Medzhitov, “Toll-Like Receptors and Innate Immunity”,Nature Reviews Immunology, vol. 1; Nov. 2001, pp. 135-145.
Jurk et al. “Human TLR7 and TLR8 independently confer responsiveness to the antiviral compound R-848”,Nature Immunology, Jun. 2002, vol. 3, No. 6; p. 1.
Akira et al., “Toll-like receptors: critical proteins linking innate and acquired immunity”,Nature Immunology, Aug. 2001, vol. 2, No. 8; pp. 675-680.
Heil et al.; “Synthetic Immunostimulatory compounds activate immune cells via TLR7 and TLR8”; 33th Annual Meeting of the Deutsche Gessellschaft für Immunologie, Marburg 2002—Abstract C.6.
Akira S. et al., Recognition of pathogen-associated molecular patterns by TLR family. Immuno. Letters. 2003, vol. 85, pp. 85-95.
Ozinsky A. et al., The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors, PNAS, Dec. 5, 2000, vol. 97, No. 25, pp. 13766-13771.
Gorden et al., “Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8”,The Journal of Immunology, 2005, vol. 174, pp. 1259-1268.
Sauder et al., “Randomized, Single-Blind, Placebo-Controlled Study of Topical Application of the Immune Respons
Fink Jason R.
Gorden Keith B.
Gorski Kevin S.
Gupta Shalley K.
Qiu Xiaohong
3M Innovative Properties Company
Bunner Bridget E
Hamud Fozia M
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