Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1986-08-01
1991-07-16
Kepplinger, Esther L.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, 514 2, 514 8, 514 21, 530350, 530351, 530395, 530402, 530403, 530404, 530408, 530825, A61K 3910, C07K 1504
Patent
active
050323989
ABSTRACT:
A modified pertussis toxin suitable as a pertussis vaccine having an essentially unmodified B-oligomer and a catalytic subunit which is inactivated by treatment with polyphosphate compounds, sulfhydryl reductants and mild detergents followed by modification of the activated --SH groups to inhibit ADP-ribosylating activity.
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Kepplinger Esther L.
Kushan Jeff
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