Selective isotopic labeling of spin labels for electron spin res

Details Selective isotopic labeling of spin labels for electron spin res Selective isotopic labeling of spin labels for electron spin res

1988-08-03

1995-07-11

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 546216, 546223, 548215, 548531, 548537, 548539, 548540, 548542, 564297, C07D20746, C07D21194

Patent

active

054319013

ABSTRACT:
Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramagnetic species, such as the determination of oxygen tension in solution or in a biological sample, like a living organism. Spin label compounds, such as nitroxides, like 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl (CTPO), are selectively, but not completely, isotopically-labeled, such as partially deuterated, to increase the sensitivity and reliability of assays employing electron spin resonance spectroscopic measurements.

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