Selective inhibitors of the urokinase plasminogen activator

Details Selective inhibitors of the urokinase plasminogen activator Selective inhibitors of the urokinase plasminogen activator

2006-05-23

2006-05-23

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S024000, C560S034000, C564S048000, C564S238000, C564S239000, C514S540000, C514S596000, C514S634000

Reexamination Certificate

active

07049460

ABSTRACT:
The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC 3.4.21.31) of the aryl guanidine type.

REFERENCES:
patent: 3257411 (1966-06-01), Patchett et al.
patent: 5656660 (1997-08-01), Lum et al.
patent: 5773644 (1998-06-01), Chen et al.
patent: 5914319 (1999-06-01), Schacht et al.
patent: 6022969 (2000-02-01), Rice et al.
patent: 6534546 (2003-03-01), Honda et al.
patent: 441366 (1968-01-01), None
patent: 947552 (1956-09-01), None
patent: WO 9920606 (1999-04-01), None
Y. Heechung et al., “Selective Inhibition of Urokinase by Substituted Phenylguanidines: Quantitative Structure-Activity Relationship Analyses,” Journal of Medicinal Chemistry, American Chemical Society, vol. 33, No. 11, 1990, p. 2956-2961.
R. Rai et al., “Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases,” Journal of Medicinal Chemistry, vol. 35, No. 22, 1992, p. 4150-9.
W. Bollag et al. “Substituted Benzylhydrazines”, Chemical Abstracts, vol. 69, No. 9, Aug. 26, 1968, abstract No. 35691c, p. 3321.

Affiliated with

Also associated with

Rating

Selective inhibitors of the urokinase plasminogen activator does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Selective inhibitors of the urokinase plasminogen activator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective inhibitors of the urokinase plasminogen activator will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3563810