Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-11-12
1998-05-05
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514299, 546 94, 546 95, 546112, 546183, C07D22122, A61K 3146
Patent
active
057475032
ABSTRACT:
The present invention provides a compound having the structure: ##STR1## wherein X, Y, and Z are independently H, Cl, Br, F, OCH.sub.3, I, or an alkyl group having 1 to 6 carbon atoms; and R is ##STR2## wherein n is 0 to 6, X' and Y' are independently H, Cl, F, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.4 H.sub.9, OCH.sub.3, OH, CF.sub.3, OCF.sub.3, NO.sub.2, NH.sub.2, N(CH.sub.3).sub.2, NHCOCH.sub.3, NCS, NHCOCH.sub.2 Br, or N.sub.3, and (CH.sub.2).sub.n, if present, may be substituted with OH, OCH.sub.3, or an alkyl or alkenyl group having 1 to 3 carbon atoms. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.
REFERENCES:
Kametani et. al., "Studies on . . . Benzazocine", Journal of Heterocyclic Chemistry, vol. 10 (1973), pp. 291-295.
Blough et. al., "Synthesis of . . . Benzazocine", Journal of Chem. Soc., Chem. Comm., No. 9 (1993), pp. 758-760.
Blough Bruce
Carroll Frank I.
Mascarella Samuel W.
Rothman Richard
Grumbling Matthew V.
Ngo Tamthom T.
Research Triangle Institute
The United States of America as represented by the Department of
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