Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-06
2006-06-06
Henley, III, Raymond J. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S429000, C514S614000
Reexamination Certificate
active
07056945
ABSTRACT:
Compositions, prodrugs and methods for inhibiting neural Nitric Oxide Synthase (nNOS). By inhibiting nNOS, the compounds, prodrugs and methods of the presnet invention are useable to treat or prevent disorders in human or veterinary patients that are caused, mediated or agrevated by Nitric Oxide within the body.
REFERENCES:
patent: 3896152 (1975-07-01), Otsuka et al.
patent: 6274557 (2001-08-01), Silverman et al.
patent: 6534546 (2003-03-01), Honda et al.
Griffith, Owen W., et al., Nitric Oxide Synthases: Properties and Cataltic Mechanism, Annual Review Physiol, 1995, 707-736, vol. 57, Annual Review, Inc.
Huang, Hui, et al., Synthesis and Evaluation of Peptidomimetics as Selective Inhibitors and Active Site Probes of Nitric Oxide Synthases, J. Medical Chemistry, 2000, 2938-2945.
Hah, Jung-Mi, et al., Reduced Amide Bond Peptidomimetics. (4S)-N-(4-Amino-5-[aminoalkyl] aminopentyl)-N-nitroguanidines, Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase, J. Medical Chemistry, 2001, 2667-2670, vol. 44, American Chemical Society.
Silverman, Richard B., et al., Selective Inhibition of Neuronal Nitric Oxide Synthase by Nw-Nitroarginine-and Phenylalanine-Containing Dipeptides and Dipeptide Esters, J. Medical Chemistry, 1997, 2813-2817, vol. 40, American Chemistry Society.
Huang, Hui, et al., N-Nitroarginine-Containing Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase, J. Medical Chemistry, 1999, 3147-3153, vol. 42, American Chemistry Society.
Taddei, Stefano, et al., Endothelial Dysfunction in Hypertension, Journal of Cardiovasular Pharmacology, 2001, S11-S14, vol. 38, Supl. 2.
Moncada, S., et al., Nitric Oxide: Physiology, Pathophysiology, and Pharmacology, Pharmacological Reviews, 1991, 109-142, vol. 43, No. 2, The American Society for Pharmacology and Experimental Therapeutics.
Grant, Stephan K., Structural Requirements for Human Inducible Nitric Oxide Synthase Substrates and Substrate Analogue Inhibitors, Biochemistry, 1998, 4174-4180, vol. 37, No. 12, American Chemical Society.
Lee, Younghee, et al., Conformationally-restricted Arginine Analogues as Alternative Substrates and Inhibitors of Nitric Oxide Synthases, Bioorganic & Medical Chemistry, 1999, 1097-1104, vol. 7.
Sachais, Bruce S., Platelet-Endothelial Interactions in Atherosclerosis, Current Atherosclerosis Reports, 2001, 412-416, vol. 3.
Dinerman, J., et al., Molecular Mechanisms of Nitric Oxide Regulation Potential Relevance to Cardiovascular Disease, 1993, 217-222, vol. 73, No. 2.
Dawson, V. L, et al., Nitric oxide in neurodegeneration, Progress in Brian Research, 1998, vol. 118, 215-229.
Kerwin, Jr., James F., et al., Nitric Oxide: A New Paradigm for Second Messengers, Journal of Medical Chemistry, 1995, 4343-4362, vol. 38, No. 22, the American Chemical Society.
Masters, B.S.S., et al., Neuronal nitric Oxide Synthase, A Modular Enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-areginine to produce NO as a cellular signal, Cythochromes, 1996, 552-558, vol. 10, The FASEB Journal.
Cho, C.H., Current roles of nitric oxide in gastrointestinal disorders, Journal of Physiology, 2001, 253-256, vol. 95, Elsevier.
Flinspach Mack
Li Huiying
Poulos Thomas
Buyan Robert D.
Henley III Raymond J.
Stout, Uxa Buyan & Mullins, LLP
The Regents of the University of California
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