Selective inhibition of gene expression by photoactivatable olig

Details Selective inhibition of gene expression by photoactivatable olig Selective inhibition of gene expression by photoactivatable olig

1989-09-21

1993-10-26

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4351723, 536 245, 514455, C12N 1500, C07H 2104

Patent

active

052566480

ABSTRACT:
A method of inhibiting the function of targeted DNA in a viable cell comprising administering to a viable cell containing targeted DNA a therapeutically effective amount of a photoactivatable composition comprising the UVA irradiation product of a compound that has two photoactivatable functional groups, and an oligonucleotide of DNA whose sequence of bases (a) contains at least one TA or AT sequence and (b) is substantially complementary to a segment of cellular DNA of the targeted DNA in the cell, and irradiating the cell with UVA light.

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