Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1999-07-20
2000-06-20
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 31201
Patent
active
060778687
ABSTRACT:
Disclosed is a method for selectively inhibiting cyclooxygenase-2 in an animal having a cyclooxygenase-2 activity by delivering into the animal an amount of a conjugated linoleic acid effective to reduce cyclooxygenase-2 activity in the animal.
REFERENCES:
patent: 4434101 (1984-02-01), Cohen et al.
patent: 5017614 (1991-05-01), Pariza et al.
patent: 5070104 (1991-12-01), Pariza et al.
patent: 5428072 (1995-06-01), Cook et al.
patent: 5430066 (1995-07-01), Cook et al.
patent: 5554646 (1996-09-01), Cook et al.
patent: 5760082 (1998-06-01), Cook et al.
patent: 5760259 (1998-06-01), Gordon et al.
patent: 5851572 (1998-12-01), Cook et al.
patent: 5914346 (1999-06-01), Cook et al.
Kim et al., Han'guk Sikp'um Yongyang Kwahak Hoechi, 26(5), 972-977 (abstract), 1997.
Cowley, Geoffrey "Getting a Grip on Pain," Newsweek (Dec. 14, 1998).
Hamberg, M., "Oxidation of Octadecatrienoic Acids in the red Alga Lithothamnion corallioides: Structural and Stereochemical Studies of Conjugated Tetraene Fatty Acids and Bis Allylic Hydroxy Acids," J. Chem. Soc, Perkin Trans. 1:3065-3072 (1993).
Hayek, et al., "Dietary Conjugated Linoleic Acid Influences the Immune Response of Young and Old C57BL/6NCrIBR Mice," J. Nutr. 129:32-38 (1999).
Li, et al., "Conjugated Linoleic Acids Alter Bone Fatty Acid Composition and Reduce ex vivo Prostaglandin E2 Biosynthesis in Rats Fed n-6 or n-3 Fatty Acids," Lipids 33:417-425 (1998).
Liu et al, "Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes," Cancer Letters 127:15-22 (1998).
Nugteren, I.H., "Inhibition of Prostaglandin Biosynthesis by 8CIS, 12TRANS, 14CIS-Eicosatetraenoic Acid," Chimica Et Biophysica Acta 210:171-176 (1970).
Proceedings, "The International Symposium Eicosanoids, Aspirin and Asthma," (Web Document, last updated Jul. 21, 1998).
Reilly, Joseph, "Nonsteroidal Anti-inflammatory Drugs: An Essential Class of Drugs Revisited," (Web Document, NY State Council of Health-System Pharmacists 1998).
Simmons et al., P.N.A.S. U.S.A. 86:1178-1182 (1989).
Sugano et al, "Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats," J. Nutritional Biochem. 8:38-43 (1997).
Sugano et al., "Conjugated Linoleic Acid Modulates Tissue Levels of Chemical Mediators and Immunoglobulins in Rats," Lipids 33:521-527 (1998).
Williams, et al., "Prostaglandin endoperoxide synthase: Why two isoforms?" Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33):G393-G400 (1996).
Li, Y. et al., "Dietary Conjugated Linoleic Acids Alter Serum IGF-I and IGF Binding Protein Concentrations and Reduce Bone Formation in Rats Fed (n-6) 0r (n-3) Fatty Acids," J. Bone Miner. Res. 14:1153-1162 (1999).
Cook Mark E
Pariza Michael W
Whigham Leah D
Spivack Phyllis G.
Wisconsin Alumni Research Foundation
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