Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2004-12-16
2010-06-22
Leavitt, Maria (Department: 1633)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S183000, C435S471000
Reexamination Certificate
active
07741071
ABSTRACT:
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
REFERENCES:
patent: 7045337 (2006-05-01), Schultz et al.
patent: 2003/0082575 (2003-05-01), Schultz et al.
patent: 2003/0108885 (2003-06-01), Schultz et al.
Biochemistry, John Wiley and Sons, 1990, p. 126-128.
Kimchi-Sarfaty Cet al., A “silent” polymorphism in the MDR1 gene changes substrate specificity.Science. Jan 26, 2007;315(5811):525-8.
Ngo et al., in the Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al., (ed.) Birkhauser, Boston, MA, pp. 492-505.
Chow et al., Mutational identification of an essential tryptophan in tryptophanyl-tRNA synthetase ofBacillus subtilis.J Biol Chem. May 5, 1992;267(13):9146-9.
Guo et al., Protein tolerance to random amino acid change.Proc Natl Acad Sci U S A. Jun 22, 2004;101(25):9205-10. Epub Jun. 14, 2004.
Liu et a., Progress toward the evolution of an organism with an expanded genetic code Proc Natl Acad Sci U S A. Apr. 27, 1999;96(9): 4780-4785.
Deiters A,et al., Adding amino acids with novel reactivity to the genetic code ofSaccharomyces cerevisiae. J Am Chem. Soc. Oct. 1, 2003;125(39):11782-3.
Marti-Renom MA, Stuart AC, Fiser A, Sanchez R, Melo F, Sali A. Comparative protein structure modeling of genes and genomes, Annu Rev Biophys Biomol Struct 2000; 29:291-325.
Biochemistry, John Wiley and Sons, pp. 126-128, 1990.
Kimchi-Sarfaty et al. “A “Silent” Polymorphism in the MDR1 Gene Changes Substrate Specificity”, Science, 26; vol. 315 p. 525 2007.
Chow et al., “Mutational Identification of an Essential Tryptophan in Tryptophany1-tRNA Synthetase ofBacillus subtillis”, J. Biol. Chem., 267(13):9146-9149 (1992).
A. K. Kowal, et al “Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria”, Proc. Natl. Acad. Sci. USA 98, 2268-2273 (2001).
Sakamoto et al., “Site-specific Incorporation of an Unnatural Amino Acid into Proteins in Mammalian Cells”, N. A. Res., vol. 30, No. 21 4692-4699, (2002).
Chin et al.(2003) “An Expanded Eukaryotic Genetic Code.”Science, 301: 964-967.
Pastrnak et al. (2000) “A New Orthogonal Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for Evolving an Organism with an Expanded Genetic Code.”Helevetica Chimica Acta. 83: 2277-2286.
Ulmasov et al. (1998) “Identity elements and aminoacylation of plant tRNATrp.”Nucleic Acids Research, 26(22): 5139-5141.
Alfonta Lital
Schultz Peter
Zhang Zhiwen
Baker Gary
Leavitt Maria
Quine Intellectual Property Law Group
The Scripps Research Institute
LandOfFree
Selective incorporation of 5-hydroxytryptophan into proteins... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Selective incorporation of 5-hydroxytryptophan into proteins..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective incorporation of 5-hydroxytryptophan into proteins... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4202872