Selective iGluR5 receptor antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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06855823

ABSTRACT:
The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5receptor antagonist. The present invention further provides novel compounds functional as selective iGluR5receptor antagonists as well as compositions and formulations comprising said selective iGluR5receptor antagonists.

REFERENCES:
patent: 5356902 (1994-10-01), Ornstein
patent: 5446051 (1995-08-01), Ornstein
patent: 5670516 (1997-09-01), Arnold et al.
patent: 5767117 (1998-06-01), Moskowitz
patent: WO 9845270 (1998-10-01), None
patent: WO 0102367 (2001-01-01), None
Procter, et al., “Possible role of GluR5 glutamate receptors in spinal nociceptive processing in the anaesthetized rat,”Journal of Physiology, 504, pp. 101P-102P (1997).
Nikam, et al., “The search for AMPA/Gly (N) receptor antagonists,”Drugs of the Future, 24(10), pp. 1107-1124 (1999).
O'Neill, MJ, et al., “Decahydroisoquinolines: Novel competitive AMPA/kainite antagonists with neuroprotective effects in global cerebral ischaemia,”Neuropharmacology, 37, pp. 1211-1222 (1998).
Proctor, MJ, et al., “Actions of kainite and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord,”Neuropharmacology, 37, pp. 1287-1297 (1998).
Bleakman, D., “Kainate receptor pharmacology and physiology,”Cellular and Molecular Life Sciences, 56/7-8, pp. 558-556 (1999).
Simmons, RM, et al., “Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat,”Neuropharmacology, 37(1), pp. 25-36 (1998).
National Library of Medicine (NLM), Bethesda, MD, US: Mitsilostas, DD, et al., “Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis,”Database accession No. 100003939&British Journal of Pharmacology, 127(3), pp. 623-630 (1999).
Sahara, Y, et al., “Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons,”The Journal of Neuroscience, 17(17), pp. 6611-6620 (1997).
Alam, A., et al., “Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache,”Journal of Neurological Sciences, 156, pp. 102-106 (1998).

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