Chemistry: analytical and immunological testing – Metal or metal containing – Zn – cd – hg – sc – y – or actinides – or lanthanides
Reexamination Certificate
2009-11-23
2011-10-11
Hill, Jr., Robert J (Department: 1777)
Chemistry: analytical and immunological testing
Metal or metal containing
Zn, cd, hg, sc, y, or actinides, or lanthanides
C548S108000, C548S305400
Reexamination Certificate
active
08034622
ABSTRACT:
Provided herein are compounds, methods of making the compounds and methods for the sensitive and selective detection of Hg2+with the compounds, which are calix[4]arenes. In particular, compounds of Formula I, wherein the variables have the values described herein, may be added to a sample to be tested for Hg2+. The compound ofFormula (I) fluoresces strongly in the absence of Hg2+but is quenched upon binding of Hg2+to form a complex. The decrease in fluorescence may be used to detect and quantify the amount of Hg2+present in a sample. The disclosed compounds may also be used to selectively detect Hg2+in samples containing other mono- or divalent metals.
REFERENCES:
Gutsche, C. D. et al., “Calixarenes. 4. The Synthesis, Characterization, and Properties of the Calixarenes fromp-tert-Butylphenol,” J. Am. Chem. Soc., vol. 103, 1981, pp. 3782-3792.
Joseph, R. et al., “Experimental and Computational Studies of Selective Recognition of Hg2+by Amide Linked Lower Rim 1,3-Dibenzimidazole Derivative of Calix[4]arene: Species Characterization in Solution and that in the Isolated Complex, Including the Delineation of the Nanostructures,” J. Org. Chem., vol. 73, 2008, pp. 5745-5758.
Joseph Roymon
Rao Chebrolu Pulla
Foley & Lardner LLP
Gerido Dwan A
Hill, Jr. Robert J
Indian Institute of Technology Bombay
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