Selective conversion of cyano compounds to amides and carboxylic

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound

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435129, 435227, 435253, 435822, C12P 1300, C12P 1302, C12N 978, C12N 120

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046297006

ABSTRACT:
A process for producing aromatic compound having at least one cyano group and one amide group or carboxyl group which process comprises subjecting aromatic polynitrile compound containing no carboxyl groups in a simple medium to the action of one or more microorganisms which have a nitrilase system capable of selectively hydrolyzing one cyano group of the polynitrile.

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Asano et al. "Degradation of Dinitriles by Fusarium Merisnoides T6-1" Agric. Biol. Chem. 44(10) 2497-2498, 1980.
Asano et al. "Fungal Degradation of Triacrylonitride" Agric. Biol. Chem. 45(1) 57-62, 1981.
Rast et al. "Degradation of Aromatic Compounds in Actinomycetes Genus Rhodococcus" Chem Abstracts vol. 92, abstract #107226e, 1980.
DiGeronimo et al. "Metabolism of Acetonitrile & Propronitrile by Nocardia Rhodochrous LL100-21" Applied & Environmental Microbiology 31(6) 900-906, 1976.
Miller et al. "Utilization of Nitrates & Amines by a Rhodococcus species" Chem. Abstracts vol. 98, abstract #31108u, 1983.
Dugan et al. "Key Enzymes in Catabolism of Aromatic Compounds of Rhodococcus" Chem. Abstracts vol. 96, abstract #241058f, 1982.
Golovlev et al. "Catabolism of Aromatic Compounds by Rhodococci of the Erythropolis Group" Chem Abstracts vol. 97, #12359j, 1982.

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