Selective capping solution phase oligonucleotide synthesis

Details Selective capping solution phase oligonucleotide synthesis Selective capping solution phase oligonucleotide synthesis

1995-06-07

1999-01-05

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2531, 536 2532, 536 2533, 536 2534, 536 254, 536 2541, C07H 2100

Patent

active

058564640

ABSTRACT:
Improved methods for solution-phase synthesis of purified short-chain oligonucleotide coupling units, such as dimers, trimers, and tetramers, suitable for use in solution-phase or solid-phase oligonucleotide synthesis are provided.

REFERENCES:
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patent: 5367066 (1994-11-01), Urdea et al.
patent: 5430136 (1995-07-01), Urdea et al.
Cormier et al., Nucleic Acid Research, vol. 16, No. 10, (1988), pp. 4583-4594.
Miura et al., "Blockwise mechanical synthesis of oligonucleotides by the phosphoramidite method" Chemical and Pharmaceutical Bulletin (1987) 35:833-836.
Seliger, "Scale-up of oligonucleotide synthesis" Methods in Molecular Biology (1993) 20:391-435.
Beaucage et al., "Deoxynucleoside phosphoramidites--a new class of key intermediates for deoxypolynucleotide synthesis" Tetra. Let. (1981) 22:1859-1862.
Hirose et al., "Rapid synthesis of trideoxyribonucleotide blocks" Tetra Lett. (1978) 28:2449-2452.
Kumar et al., "Improvements in oligodeoxyribonucleotide synthesis: Methyl N,N-dialkylphosphoramidite dimer units for solid support phosphite methodology" J. Org. Chem. (1984) 49:4905-4912.

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