Selective biologically active 7-oxo-prostacyclin derivatives and

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai

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Details

514460, 514470, 549214, 549415, 549465, A61K 31557, A61K 3134, C07D307935

Patent

active

045887136

ABSTRACT:
Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation,
R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl,
A stands for ethylene, cis or trans-vinylene or --C.dbd.C--,
n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

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