Selective .beta..sub.3 agonists for the treatment of diabetes an

Details Selective .beta..sub.3 agonists for the treatment of diabetes an Selective .beta..sub.3 agonists for the treatment of diabetes an

1996-09-23

1998-02-03

Northington-Davis, Zinna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514357, 546309, 546312, 546334, A61K 3144, C07D21330

Patent

active

057145067

ABSTRACT:
Compounds of formula ##STR1## are selective .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents.

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Bobowski et al, J. of Heterocyclic Chemistry, vol. 19, No. 1, Jan.-Feb., 1982, pp. 21-27.

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