Selective asymmetric hydrogenation of dehydroamino acid derivati

Details Selective asymmetric hydrogenation of dehydroamino acid derivati Selective asymmetric hydrogenation of dehydroamino acid derivati

1995-04-24

1996-04-23

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 39, 562444, 562449, 562450, 549 77, 549 76, C07C22934

Patent

active

055105076

ABSTRACT:
A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wherein the phosphorous atoms are attached to aromatic groups substituted with electron-donating substituents. Also provided is a means to selectively produce .alpha. amino acids in either the L or the D form, based upon use of a sugar in the ligand with phosphinites attached in an absolute Right-Left or Left-Right configuration, respectively.

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