Selective asymmetric hydrogenation of dehydroamino acid derivati

Details Selective asymmetric hydrogenation of dehydroamino acid derivati Selective asymmetric hydrogenation of dehydroamino acid derivati

1994-01-11

1996-01-02

Nazario-Gonzales, Profirio

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

502166, 556136, 556137, C07F 1500, B01J 3100

Patent

active

054810060

ABSTRACT:
A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wherein the phosphorous atoms are attached to aromatic groups substituted with electron-donating substituents. Also provided is a means to selectively produce .alpha. amino acids in either the L or the D form, based upon use of a sugar in the ligand with phosphinites attached in an absolute Right-Left or Left-Right configuration, respectively.

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