Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ether doai
Patent
1991-09-30
1993-06-01
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ether doai
514716, 514728, 514772, 514832, A01N 3114, A01N 3318, A01N 2500
Patent
active
052160327
ABSTRACT:
A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart of said subject, such as a perfluorochemical blood substitute. Following perfusion, spontaneous circulation is restored.
In an improved embodiment of the foregoing, a vasoconstrictor such as epinephrine is administered concurrently with the perfusing step in an amount effective to enhance coronary perfusion with said protective solution.
REFERENCES:
patent: 3962439 (1976-06-01), Yokoyama
The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Ed.) (Susan Budavari et al., Ed.) (Merck & Co., Inc., Rahway, N.J. 1989), pp. 392, 625, 933, 1131.
G. Martin et al., Annals of Emergency Medicine 15, 125-130 (1986).
B. Hoffman and J. Bigger, Jr. "Digitalis and Allied Cardiac Glycosides" in Goodman and Gilman's The Pharmacological Basis of Therapeutics (7th Ed.) (Macmillan Publishing Company, N.Y. 1985), pp. 716-718.
A. Bajaj et al., "Limitation of Myocardial Reperfusion Injury by Intravenous Perfluorochemicals," Circulation 79, 645-655 (1989).
L. Becker et al., "Outcome of CPR in a Large Metropolitan Area-Where are the Survivors?" Annals of Emergency Medicine 20, 355-361 (1991).
M. Cleman et al., "Prevention of Ischemia During Percutaneous Transluminal Coronary Angioplasty by Transcatheter Infusion of Oxygenated Fluosol DA 29%", Circulation 74, No. 3, 555-562 (1986).
C. Emerman et al., "Hemodyamic Effects of the Intra-aortic Balloon Pump During Experimental Cardiac Arrest," Am. J. Emerg. Med. 7, 378-382 (1989).
H. Memezawa et al., "Effects of Fluosol-DA on Brain Edema, Energy Metabolites, and Tissue Oxygen Content in Acute Cerebral Ischemia," Advances in Neurology 52, 109-118 (1990).
Martin Physical Pharmacy, pp. 276-277 1983.
Goodman The Pharmacological Basis of Therapeutics pp. 491, 1975.
Novick et al. "Protection of . . . " J. Thoracic and Cardio. Surg 89: 547-566 (1985).
Hook Gregory
The University of North Carolina at Chapel Hill
Waddell Frederick E.
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