Selective antagonists of A 2A adenosine receptors

Details Selective antagonists of A 2A adenosine receptors Selective antagonists of A 2A adenosine receptors

2011-07-26

2011-07-26

Berch, Mark L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S263400, C544S277000

Reexamination Certificate

active

07985754

ABSTRACT:
The present invention provides compounds of formulae Ia and Ib:wherein R1-5, Q, X, Y, Z, p, q, and r are as defined herein. The compounds are potent and selective antagonists of A2Aadenosine receptors (ARs). The invention further includes pharmaceutical compositions containing these compounds and methods of using the same.

REFERENCES:
patent: 2007/0270373 (2007-11-01), Rieger et al.
patent: 2008/0009460 (2008-01-01), Linden et al.
patent: 2008/0027022 (2008-01-01), Linden et al.
patent: 2008/0262001 (2008-10-01), Kranenburg et al.
patent: 2008/0312160 (2008-12-01), Guerrant et al.
patent: 2009/0181920 (2009-07-01), Watkins et al.
patent: 2009/0280059 (2009-11-01), Rieger et al.

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