Selective amylin antagonist peptides and uses therefor

Details Selective amylin antagonist peptides and uses therefor Selective amylin antagonist peptides and uses therefor

1993-07-21

1997-04-29

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, A61K 3816, C07K 1400

Patent

active

056250320

ABSTRACT:
Peptides that inhibit amylin activity and that exhibit selectivity for amylin receptors relative to calcitonin and CGRP receptors are provided. These peptides may be used in the treatment of conditions where it is of benefit to reduce amylin activity, including the treatment of Type 2 diabetes mellitus, impaired glucose tolerance, obesity, insulin resistance and hypertension.

REFERENCES:
patent: 5260275 (1993-11-01), Cooper et al.
Patel, Biochem Soc. Trans., 17(5) 1989, p. 931.
McMartin, Biochem. Soc. Trans. 17(5) 1989, pp. 931-934.
Bundgaard et al., Biochem Soc. Trans., 17(5) 1989, pp. 947-949.
Morrison and Boyda, Organic Chemistry, 4th Ed., Allyn and Bacon, Inc., 1983, pp. 1117-1120.
U.S. Application Serial No. 07/794,288, filed Nov. 19, 1992, for "Novel Amylin Antagonist Peptides and Uses Therefor".
Amara, S.G. et al., Science 229:1094-1097 (1985).
Cooper, G.J.S. et al., Proc. Natl. Acad. Sci. USA 85:7763-7766 (1988).
Cooper, G.J.S. et al., Proc. Natl. Acad. Sci. USA 85:7763-7766 (1988).
Cooper, G.J.S. et al., Biochem. Biophys. Acta. 1014:247-258 (1989).
Cooper, G.J.S. et al., Progress in Growth Factor Research 1:99-105 (1989).

Affiliated with

Also associated with

Rating

Selective amylin antagonist peptides and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Selective amylin antagonist peptides and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective amylin antagonist peptides and uses therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-706775