Selective aliphatic C-H oxidation

Details Selective aliphatic C-H oxidation Selective aliphatic C-H oxidation

2008-10-03

2010-11-09

Gakh, Yelena G (Department: 1797)

Chemistry: analytical and immunological testing

Oxygen containing

C502S100000, C502S167000, C546S002000

Reexamination Certificate

active

07829342

ABSTRACT:
A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp3C—H bond oxidation. The tetradentate ligand may include a N-heterocyclic-N,N′-bis(pyridyl)-ethane-1,2-diamine group or a N,N′-bis(heterocyclic)-N,N′-bis(pyridyl)-ethane-1,2-diamine group. The composition can be used in combination with H2O2to effect highly selective oxidations of unactivated sp3C—H bonds over a broad range of substrates. The site of oxidation can be predicted, based on the electronic and/or steric environment of the C—H bond. In addition, the oxidation reaction does not require the presence of directing groups in the substrate.

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