Selective adenosine receptor agents

Details Selective adenosine receptor agents Selective adenosine receptor agents

1994-03-08

1995-02-21

Chang, Celia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544362, A61K 3152, C07D47334

Patent

active

053917391

ABSTRACT:
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo.
Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

REFERENCES:
patent: 3092632 (1963-06-01), Zwahlen
patent: 3114751 (1963-12-01), Whetstone
patent: 3211732 (1965-10-01), Schmidt
patent: 3225029 (1965-12-01), Yaniaoka
patent: 3225046 (1965-12-01), Zwahlen
patent: 3399196 (1968-08-01), Druey et al.
patent: 3502649 (1970-03-01), Thiel
patent: 3590029 (1971-06-01), Koch et al.
patent: 3813394 (1974-05-01), Tensho et al.
patent: 3862189 (1975-01-01), Schwender
patent: 3930005 (1975-12-01), Wojnar
patent: 3936454 (1976-02-01), Schwender
patent: 4388308 (1983-06-01), Hamilton et al.
patent: 4514405 (1985-04-01), Irmscher
patent: 4853368 (1989-08-01), Friebe et al.
patent: 4904666 (1990-02-01), Friebe et al.
patent: 4954504 (1990-09-01), Chen et al.
patent: 5043325 (1991-07-01), Olsson
patent: 5110818 (1992-05-01), Allgeier
Lira et al "Cyclization of substituted N-(purin-6yl)-2-amino ethanol system." CA 69:52101c (1968).
Friebe et al "Derivatives of N.sup.6 -substituted adenine" CA 84:105656y (1976).
Matsubara et al "Growth-promoting activity of optically active cytokinins in tobacco tissue culture" CA 87:178878b (1977).
Brajeswar et al., J. Med. Chem, 18 (10) 968-973 (1975).
Chem Abstract, Brajwswar et al., 83:172423V RN 56904-93-3 (1975).
J. L. Avila et al., Comp. Biochem Physiol., 86 C(1), 49-54 (1987).
J. L. Avila et al., Comp. Biochem Physiol., 83 C(2), 285-89 (1986).
C. C. Chang, et al., Contribution form the Dept. of Chem., New Mexico Highlands Univ. 1240-56 (1956).
E. Y. Sutcliffe, et al. J. Med. Pharm. Chem., 5, 588-607 (1957).
H. E. Skipper et al., Cancer Res., 17, 579-96 (1957).
B. J. Lynch, et al., Contribution form the Dept. of Chem., New Mexico Highlands Univ. 2973-81 (1958).
G. A. Bhat, et al., J. Med. Chem, 26 1165-72 (1981).
Chem Abstract, vol. 98, (1983) p. 50, 172752.
Chem Abstract, vol. 105, (1986), 227205.
Chem Abst., vol. 52, May 19, (1958), pp. 7324-7335.
J. W. Daly et al., Biochem. Pharm., 35 (15) 2467-2481 (1986).
Chang et al. J. Org. Chem., 23, 191-200 (1958).
Koppel et al. Am. Chem. Soc. J., 80, pp. 2751-2755 (1958).

Affiliated with

Also associated with

Rating

Selective adenosine receptor agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Selective adenosine receptor agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective adenosine receptor agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1931352