Selective adenosine receptor agents

Details Selective adenosine receptor agents Selective adenosine receptor agents

1992-09-30

1993-10-26

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514258, 514261, 536 276, 536 2761, 536 2762, 536 2763, 544262, 544277, C07H 1906, C07D47330, A61K 3170

Patent

active

052566501

ABSTRACT:
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo.
Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

REFERENCES:
patent: 3211732 (1965-10-01), Schmidt
patent: 3225046 (1965-12-01), Zwahlen
patent: 3502649 (1970-03-01), Thiel
patent: 3590029 (1971-06-01), Koch
patent: 3862189 (1975-01-01), Schwender
patent: 4388308 (1983-06-01), Hamilton
patent: 4514405 (1985-04-01), Irmscher
patent: 4853386 (1989-08-01), Friebe
patent: 4904666 (1990-02-01), Friebe
patent: 5043325 (1991-08-01), Olsson

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