Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1990-03-26
1991-09-10
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
544272, 544273, A61K 3152, C07D47312
Patent
active
050475347
ABSTRACT:
Xanthine derivative which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectively and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo.
Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.
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K. A. Jacobson et al., Molecular Probes for Extracellular Adenosine Receptors, Biochemical Pharm., 36(10), 1697-1707 (1987).
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L. Capuano, Synthese von Thieno, Tetrahydrobenzothieno-, Pyrazolo-, Triazolo- und Pyrido-Pyrimidinen Sowie Naphth- und Thien-Oxazinen, Chem. Ber., 102, 3698-3706 (1969).
EP Application 203721, Published 12/3/86, [Derwent Abstract 86-320644 provided].
Lentz Nelson L.
Peet Norton P.
Grumbling Matthew V.
Merrell Dow Pharmaceuticals Inc.
Shah Mukund J.
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