Selective acylation process

Details Selective acylation process Selective acylation process

1984-09-28

1986-06-03

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603975, 546 1, C07J 100

Patent

active

045928690

ABSTRACT:
This invention relates to a selective acylation process for the preparation of phenolic N-disubstituted carbamate esters of steroids, comprising reacting in an inert solvent an acylating agent being a carbamoyl halogenide, a 4-(tertiary amino)-pyridine, or a complex thereof, optionally as a part of a polymer and a steroid having at least two free hydroxy groups, where at least one is phenolic and at least one is alcoholic, optionally in the presence of an acid acceptor.

REFERENCES:
patent: 4180504 (1979-12-01), Hansen et al.
Steroids, (1984), vol. 44, No. 1, pp. 85-93.
Delaney, E. J. et al., in J. Am. Chem. Soc. 104, (1982), 799-807.
Tomoi, M. et al., in Makromol. Chem. Rapid Commun. 3, (1982), 537-542.

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