Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Patent
1994-11-17
1997-07-08
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
A61K 3828, C07K 1462
Patent
active
056462425
ABSTRACT:
The present invention relates to the acylation of proteins. More particularly, the invention relates to a one-step process for selectively acylating the free .epsilon.-amino group of insulin, insulin analog, or proinsulin in the presence of a free .alpha.-amino group.
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Baker Jeffrey C.
Chen Victor J.
Hanquier Jose M.
Kriauciunas Aidas
Moser Brian A.
Boone David E.
Caltrider Steven P.
Eli Lilly and Company
Maciak Ronald S.
Nucker Christine M.
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